# Microfluidics & Lab-on-a-chip Research Group (MLRG)

### Members:

- Barbaros Çetin
- Soheila Zeinali
- Serdar Taze
- İlbey Karakurt (UG)
- Erdem Çagatay (UG)

### Projects:

- Development of a lab-on-a-chip device for the manipulation of microparticles using AC-dielectrophoresis and acoustic methods
- Design of a microfluidic platform real time, continuous flow PCR reactor
- Boundary element formulation of particle flow in a microchannel
- Development of a microfluidic device for synthesis of chitosan nanoparticles
- Analysis of single phase fluid flow and heat transfer in slip-flow regime by parallel implementation of Lattice-Boltzmann Method on GPUs
- Development and fabrication of micro-grooved heat pipes for high-flux electronic cooling applications
- Development of a microfluidic device for particle counting and the application of the device for the determination of the total viable count and the number of somatic cells in reference milk sample

### Activities:

The miniaturization trend of electronic components since 1970’s and the development of advanced fabrication techniques for micro and nanoscale devices since 1980’s led to the usage of devices having the dimensions of micrometers and nanometers in many fields. As a consequence a field of microfluidics which deals with fluid flow phenomena at microscale became an interesting, rich research field. Fundamental understanding of the fluid, thermal and mass transport at microscale is very critical for the design and process control of the microfluidic systems.**Lab-on-a-chip (LOC)**devices are the microfluidic platforms that can integrate complex chemical management and analysis systems onto one chip just millimeters or centimeters in size and can be interfaced with electronics and optical detection systems. The ultimate goal of the LOC technology is to develop portable devices that can accomplish the same analytical tasks fast and accurately as its room-sized or benchtop-sized counterparts, however, at much lower manufacturing and operational cost, and more importantly which can accomplish in-situ testing and detection. This kind of devices are being demanded by life sciences, space explorations, defense industry, atmospheric sciences, pharmaceutical research etc.

**Bilkent University Microfluidics & Lab-on-a-chip Research Group (BU-MLRG)**’s interest lies in the fundamental and experimental investigations on transport phenomena in microchannel networks and development of the LOC technology for biomedical, biological and chemical applications.

Research directions of

**BU-MLRG**are summarized below. Dashed lines indicate the future research directions.

**BU-MLRG**collaborates

**(i)**with

*Micro System Design and Manufacturing Center*within the department for the fabrication phase of the lab-on-a-chip devices,

**(ii)**with

*Asst. Prof. Dr. Bülent Özer (TOBB ETU-ME)*for the application of acoustic methods in LOC devices,

**(iii)**with

*Asst. Prof. Dr. Besim Baranoğlu (Atılım Uni.-MFGE)*on the development of a boundary element formulation of particle flow in a microchannel,

**(iv)**with

*Prof. Dr. Zafer Dursunkaya (METU-ME)*for the modeling and development micro-groove heat pipes for high heat-flux electronics cooling, and

**(v)**with

*Prof. Dr. Kevin Cole (The Uni. Nebraska, ME)*on the development of Green's function based analytical techniques for the analysis of heat transfer in microchannels.

Effective as of

**Fall 2014**, there are

**several positions**for

**qualified and dedicated graduate students**available within

**BU-MLRG**for the following projects:

1. Development and fabrication of micro-grooved heat pipes for high-flux electronic cooling applications

2. Boundary element formulation of particle flow in a micro channel under the action of electrokinetic and acoustic forces

3. Development of high-througput microfluidic device for separation by size using 3D microchannel topology

4. Design of a microfluidic device for sperm separation

5. Development of a microfluidic device for synthesis and separation of chitosan naoparticles

Prospective graduate students should see Bilkent's Graduate Programs website for online application instructions and the minimum requirements for the application.

### Publications:

- Microscale Acoustofluidics, Encyclopedia of Micro and Nanoﬂuidics (2nd Edition, Springer, 2014)
- Methods for Pressure Measurements, Encyclopedia of Micro and Nanoﬂuidics (2nd Edition, Springer, 2014)
- Ultrasonic pumps, Encyclopedia of Micro and Nanoﬂuidics (Springer, 2008, ISBN: 978-0-387-49000-7)
- Microﬂuidic Optical Devices, Encyclopedia of Micro and Nanoﬂuidics (Springer, 2008, ISBN: 978-0-387-49000-7)
- Magnetic Pumps, Encyclopedia of Micro and Nanoﬂuidics (Springer, 2008, ISBN: 978-0-387-49000-7)
- Methods for Pressure Measurements, Encyclopedia of Micro and Nanoﬂuidics (Springer, 2008, ISBN: 978-0-387-49000-7)
- Temperature Gradient Generation and Control, Encyclopedia of Micro and Nanoﬂuidics (Springer, 2008, ISBN: 978-0-387-49000-7)
- Microﬂuidic Rotary Pump, Encyclopedia of Micro and Nanoﬂuidics (Springer, 2008, ISBN: 978-0-387-49000-7)
- Baranoğlu, B., Çetin, B. (2014). "A particle flow specific boundary element formulation for microfluidic applications",
*4th Micro and Nano Flows Conference*, September 7-10, University College London, UK - Çetin, B., Zeinali, S. (2014). "Modeling of on-chip (bio)particle separation and counting using 3D electrode structures",
*4th Micro and Nano Flows Conference*, September 7-10, University College London, UK - Büyükkoçak, S., Özer, B., Çetin, B. (2014). "Finite element modeling of micro-particle manipulation using ultrasonic standing waves",
*ASME 12th International Conference on Nanochannels, Microchannels and Minichannels*, August 3-7, Chicago, IL, USA - Barbaros Çetin,, Serdar Taze,, Z. Dursunkaya, (2014). "Multi-physics modeling of silicon-based micro-grooved heat pipe",
*4th European Microfluidics Conference*, December 10-12, Limerick, Ireland (Abstract submitted) - Karakurt, İ., Çetin, B. (2014). "Multiphysics simulation of microfluidic reactor for polymerase chain reaction",
*International Symposium on Convective Heat and Mass Transfer (CONV-14), Paper No: 79*, June 8-13, Kuşadası, Aydın, Turkey

Full Text - Cetin, B., Özer, B., Zeinali, S., Büyükkoçak, S. (2014). "Fabrication of microfluidic devices for dielectrophoretic and acoustophoretic applications using high-precision machining",
*16th Int. Conference on Machine Design and Production (UMTIK-2014)*, June 30 - July 3, Izmir, Turkey

Full Text - Çetin, B., Büyükkoçak, S., Zeinali, S., Özer, B. (2013). "Simulation of an integrated microfluidic device for bioparticle wash, separation and concentration",
*Proc. ASME 2013 4th Microscale/Nanoscale Heat & Mass Transfer International Conference*, December 11-14, Hong Kong, China

DOI: 10.1115/MNHMT2013-22181 - Salemmilani, R., Çetin, B. (2013). "Spiral microﬂuidic device for continuous ﬂow PCR",
*ASME 2013 Summer Heat Transfer Conference*(17305) p.V002T11A001, July 14–19, Minneapolis, MN, USA

DOI: 10.1115/HT2013-17305 - Çetin, B., Taze, S., Aşık, M., Tuncel, A. (2013). "Microfluidic device for synthesis of chitosan nanoparticles",
*ASME 2013 Fluid Engineering Summer Meeting*(16349) p.V002T21A006, July 7-11, Incline village, Nevada, USA

DOI: 10.1115/FEDSM2013-16349 - Çetin, B. (2012). "Evaluation of Nusselt number for a ﬂow in a microtube with second-order model including thermal creep",
*10th International Conference on Nanochannels, Microchannles and Minichannels (ICNMM’2012)*(73321) p.251-256, July 8–12, Puerto Rico, USA

DOI: 10.1115/ICNMM2012-73321 - Gürol, Y., Çelik, S., Çetin, B. (2011). "Simulation of 2D electro-osmotic flow inside microchannels using Lattice-Boltzmann method on GPUs",
*18th National Conference on Thermal Sciences*, September 7-10, Zonguldak, Turkey

Full Text - Güler, K., Çetin, B. (2011). "Simulation of elektrokinetic manipulation of particle inside microchannels",
*18th National Conference on Thermal Sciences*, September 7-10, Zonguldak, Turkey

Full Text - Çetin, B., Taze, S., Ozturk, Y. (2011). "Viscous flow calculations for undergraduate fluid mechanics education using MATLAB",
*18th National Conference on Thermal Sciences*, September 7-10, Zonguldak, Turkey

Full Text - Çelik, B., Sert, C., Çetin, B. (2011). "Simulation of channel flow by parallel implementation of thermal Lattice-Boltzmann method on GPUs",
*7th International Conference on Computational Heat and Mass Transfer (ICCHMT'2011)*, July 18-22, Istanbul, Turkey

Full Text - Çelik, B., Sert, C., Çetin, B. (2011). "Simulation of lid-driven cavity flow by parallel implementation of Lattice-Boltzmann method on GPUs",
*2nd International Symposium on Computing in Science and Engineering (ISCSE'11)*, June 1-4, Kusadasi, Aydin, Turkey

Full Text - Çetin, B., Bayer, O. (2010). "Evaluation of Nusselt number for a flow in a microtube with constant heat flux including axial conduction, viscous dissipation and second-order slip model",
*The 3rd International Symposium on Nonlinear Dynamics (ISND 2010)*, September 25-28, Shanghai, China

Full Text - Çetin, B., Li, D. (2008). "Microfluidic continuous particle separation via AC-DEP with 3D electrodes",
*ASME International Mechanical Engineering Congress and Exposition (IMECE'08)*p.217-222, October 31-November , Boston, MA, USA

DOI: 10.1115/IMECE2008-67417 - Çetin, B., Li, D. (2007). "Modeling and simulation of 2D, EOF in a slit channel with Joule heating effect",
*16th National Conference on Thermal Sciences*, May 30-June 2, Kayseri, Turkey

Full Text - Bulut, B., Çetin, B., Yazıcıoğlu, A., Yuncu, H., Kakaç, S. (2007). "The analysis of the effect of axial conduction on single-phase convective heat transfer in microtubes",
*16th National Conference on Thermal Sciences*, May 30-June 2, Kayseri, Turkey

Full Text - Çetin, B., Yuncu, H., Kakaç, S. (2005). "Single-phase convective heat transfer in microtubes",
*15th National Conference on Thermal Sciences*, September 7-9, Trabzon, Turkey

Full Text - Bayer, O., Çetin, B., Dirgin, E. (2003). "COP-Irreversibility relation in household refrigerators",
*14th National Conference on Thermal Sciences*, September, 3-5, Isparta, Turkey

Full Text - Çetin, B., Zeinali, S. (2014). "Analysis of heat transfer for a low Peclet number microtube flow using second-order slip model: An extended-Graetz problem",
*J. Engineering Mathematics*

Full Text | DOI: 10.1007/s10665-014-9704-7 - Büyükkoçak, S., Özer, B., Çetin, B. (2014). "Numerical modeling of acoustophoretic particle separation for microfuildics",
*Microfluid Nanofluid (available online)*

Full Text | DOI: 10.1007/s10404-014-1398-7 - Cole, K., Çetin, B., Brettmann, L. (2014). "Microchannel heat transfer with slip flow and wall effects",
*AIAA J. Thermophysics and Heat Transfer*, v.28(3) p.455-462

Full Text | DOI: 10.2514/1.T4267 - Çetin, B., Aşık, M., Taze, S. (2014). "Design and fabrication of a microﬂuidic device for synthesis of chitosan nanoparticles",
*ASME J. Nanotechnology in Engineering and Medicine*, v. 4(3) p.031004

Full Text | DOI: 10.1115/1.4026287 - Çetin, B., Çelik, B., Sert, C. (2014). "Analysis of heat transfer in slip-flow regime by parallel implementation of Lattice-Boltzmann method on GPUs",
*Submitted to Thermal Science* - Cetin, B., Ozer, B., Solmaz, M. (2014). "Microfluidic bio-particle manipulation for biotechnology",
*Biochemical Engineering Journal (available online)*

Full Text | DOI: 10.1016/j.bej.2014.07.013 - Çetin, B. (2013). "Effect of thermal creep on heat transfer for a 2D microchannel flow: An analytical approach",
*ASME J. Heat Transfer, Special Issue on Microchannel Heat Transfer*, v.135(10) p.101007

Full Text | DOI: 10.1115/1.4024504 - Çetin, B., Cole, K. (2011). "The effect of axial conduction on heat transfer in a liquid microchannel flow",
*Int. J. Heat and Mass Transfer*, v.54 p. 2542-2549

DOI: 10.1016/j.ijheatmasstransfer.2011.02.007 - Çetin, B., Bayer, O. (2011). "Evaluation of Nusselt number for a flow in a microtube using second-order slip model",
*Thermal Science*, v.15(Suppl. 1) p.103-109

DOI: 10.2298/TSCI11S1103C - Çetin, B., Li, D. (2011). "Dielectrophoresis in microfluidics technology",
*Electrophoresis, Special Issue on Dielectrophoresis*, v.32 p.2410–2427

DOI: 10.1002/elps.201100167 - Çetin, B., Li, D. (2010). "Lab-on-a-chip device for continuous particle and cell separation based on electrical properties via AC-dielectrophoresis
",
*Electrophoresis*, v.31 p.3035-3043

DOI: 10.1002/elps.20090007830 - Çetin, B., Yazıcıoğlu, A., Kakaç, S. (2009). "Slip-flow heat transfer in microtubes with axial conduction and viscous dissipation-an extended Graetz problem",
*Int. J. Thermal Sciences*, v.48 p.1673-1678

DOI: 10.1016/j.ijthermalsci.2009.02.002 - Çetin, B., Kang, Y., Wu, Z., Li, D. (2009). "Continuous particle separation by size via AC-DEP using a lab-on-a-chip device with 3D electrodes",
*Electrophoresis*, v.30 p.766-772

DOI: 10.1002/elps.200800464 - Çetin, B., Li, D. (2009). "Continuous particle separation based on electrical properties using AC-DEP",
*Electrophoresis*, v.30 p.3124-3133

DOI: 10.1002/elps.20090007830 - Çetin, B., Kang, Y., Wu, Z., Li, D. (2009). "Continuous particle separation with localized AC-DEP using embedded electrodes and an insulating hurdle",
*Electrochimica Acta*, v.54 p.1715-1720

DOI: 10.1016/j.electacta.2008.09.062 - Çetin, B., Yazıcıoğlu, A., Kakaç, S. (2008). "Fluid Flow in microtubes with axial conduction including rarefaction and viscous dissipation",
*Int. Comm. Heat and Mass Transfer*, v.35 p.535-544

DOI: 10.1016/j.icheatmasstransfer.2008.01.003 - Çetin, B., Travis, B., Li, D. (2008). "Analysis of the electro-viscous effects on pressure-driven liquid flow in a two-section heterogeneous microchannel",
*Electrochimica Acta*, v.54 p.660-664

DOI: 10.1016/j.electacta.2008.07.008 - Çetin, B., Li, D. (2008). "Effect of Joule heating on electrokinetic transport",
*Electrophoresis*, v.29(5) p.994-1005

DOI: 10.1002/elps.200700601 - Çetin, B., Yuncu, H., Kakaç, S. (2006). "Gaseous flow in microconduits with viscous dissipation",
*Int. J. Transport Phenomena*, v.8(4) p.297-315

Full Text - A. Koray Koska (Advisor: Asst. Prof. Dr. Barbaros Çetin), (2013). "Injection molding of polymeric microfluidic devices",
*Bilkent University, Mechanical Engineering Department* - S. Berat Çelik (Co-advisor: Asst. Prof. Dr. Barbaros Cetin), (2012). "Analysis of single phase fluid flow and heat transfer in slip-flow regime by parallel implementation of Lattice-Boltzmann Method on GPUs",
*METU, Department of Mechanical Engineering*, Ankara, Turkey - Cetin, B. (2005). "Analysis of Single Phase Convective Heat Transfer in Microtubes and Microchannels",
*METU, Department of Mechanical Engineering*, Ankara, Turkey

Full Text - Cetin, B. (2009). "Microﬂuidic Continuous Separation of Particles and Cells by using AC-Dielectrophoresis",
*Vanderbilt University, Department of Mechanical Engineering*, Nashville, TN, USA

Full Text