Group

Microfluidics & Lab-on-a-chip Research Group (MLRG)

Members:

Projects:

Activities:

The miniaturization trend of electronic components since 1970’s and the development of advanced fabrication techniques for micro and nanoscale devices since 1980’s led to the usage of devices having the dimensions of micrometers and nanometers in many fields. As a consequence a field of microfluidics which deals with fluid flow phenomena at microscale became an interesting, rich research field. Fundamental understanding of the fluid, thermal and mass transport at microscale is very critical for the design and process control of the microfluidic systems.

Lab-on-a-chip (LOC) devices are the microfluidic platforms that can integrate complex chemical management and analysis systems onto one chip just millimeters or centimeters in size and can be interfaced with electronics and optical detection systems. The ultimate goal of the LOC technology is to develop portable devices that can accomplish the same analytical tasks fast and accurately as its room-sized or benchtop-sized counterparts, however, at much lower manufacturing and operational cost, and more importantly which can accomplish in-situ testing and detection. This kind of devices are being demanded by life sciences, space explorations, defense industry, atmospheric sciences, pharmaceutical research etc.

Bilkent University Microfluidics & Lab-on-a-chip Research Group’s interest lies in the fundamental and experimental investigations on transport phenomena in microchannel networks and development of the LOC technology for biomedical, biological and chemical applications.

Research directions of BU-MLRG are summarized below. Dashed lines indicate the future research directions.


MLRG collaborates with Micro System Design and Manufacturing Center within the department for the fabrication phase of the lab-on-a-chip devices, with Asst. Prof. Dr. Bulent Ozer (TOBB ETU-ME) for the application of acoustic methods in lab-on-a-chıp devices, and with Asst. Prof. Dr. Cuneyt Sert (METU-ME) for the implementation of Lattice-Boltzmann method together with GPU-computing for the modeling of fluid flow and heat transfer at microscale.

Publications:

  • Boundary-Element Method in Microfluidics, Encyclopedia of Micro and Nanofluidics (2nd Edition, Springer, 2013)

  • Microscale Acoustofluidics, Encyclopedia of Micro and Nanofluidics (2nd Edition, Springer, 2013)

  • Ultrasonic pumps, Encyclopedia of Micro and Nanofluidics (Springer, 2008, ISBN: 978-0-387-49000-7)

  • Microfluidic Optical Devices, Encyclopedia of Micro and Nanofluidics (Springer, 2008, ISBN: 978-0-387-49000-7)

  • Magnetic Pumps, Encyclopedia of Micro and Nanofluidics (Springer, 2008, ISBN: 978-0-387-49000-7)

  • Methods for Pressure Measurements, Encyclopedia of Micro and Nanofluidics (Springer, 2008, ISBN: 978-0-387-49000-7)

  • Temperature Gradient Generation and Control, Encyclopedia of Micro and Nanofluidics (Springer, 2008, ISBN: 978-0-387-49000-7)

  • Microfluidic Rotary Pump, Encyclopedia of Micro and Nanofluidics (Springer, 2008, ISBN: 978-0-387-49000-7)

    • Conference Papers

  • Cetin, B., Taze, S., Asik, M., Tuncel, A. (2013). "Microfluidic device for synthesis of chitosan nanoparticles", ASME 2013 Fluid Engineering Summer Meeting , July 7-11, Incline village, Nevada, USA (Accepted)

  • Cetin, B., Buyukkocak, S., Zeinali, S., Ozer, M. (2013). "Simulation of an integrated microfluidic device for bioparticle wash, separation and concentration", ASME 2013 4th Microscale/Nanoscale Heat & Mass Transfer International Conference, December 11-14, Hong Kong, China (Abstract submitted)

  • Salemmilani, R., Çetin, B. (2013). "Spiral microfluidic device for continuous flow PCR", ASME 2013 Summer Heat Transfer Conference, July 14–19, Minneapolis, MN, USA (Accepted)

  • Cetin, B. (2012). "Evaluation of Nusselt number for a flow in a microtube with second-order model including thermal creep", 10th International Conference on Nanochannels, Microchannles and Minichannels (ICNMM’2012)(73321), July 8–12, Puerto Rico, USA

  • Gurol, Y., Çelik, B., Çetin, B. (2011). "Simulation of 2D electro-osmotic flow inside microchannels using Lattice-Boltzmann method on GPUs", 18th National Conference on Thermal Sciences , September 7-10, Zonguldak, Turkey

  • Guler, K., Çetin, B. (2011). "Simulation of elektrokinetic manipulation of particle inside microchannels", 18th National Conference on Thermal Sciences, September 7-10, Zonguldak, Turkey

  • Çetin, B., Taze, S., Ozturk, Y. (2011). "Viscous flow calculations for undergraduate fluid mechanics education using MATLAB", 18th National Conference on Thermal Sciences, September 7-10, Zonguldak, Turkey

  • Çelik, B., Sert, C., Çetin, B. (2011). "Simulation of channel flow by parallel implementation of thermal Lattice-Boltzmann method on GPUs", 7th International Conference on Computational Heat and Mass Transfer (ICCHMT'2011), July 18-22, Istanbul, Turkey

  • Çelik, B., Sert, C., Çetin, B. (2011). "Simulation of lid-driven cavity flow by parallel implementation of Lattice-Boltzmann method on GPUs", 2nd International Symposium on Computing in Science and Engineering (ISCSE'11), June 1-4, Kusadasi, Aydin, Turkey

  • Çetin, B., Li, D. (2010). "Lab-on-a-chip device for continuous particle and cell separation based on electrical properties via AC-dielectrophoresis", 17th International Symposium on Capillary Electroseperation Techniques (ITP 2010), August 29-September , Baltimore, MD, USA

  • Çetin, B., Bayer, O. (2010). "Evaluation of Nusselt number for a flow in a microtube with constant heat flux including axial conduction, viscous dissipation and second-order slip model", The 3rd International Symposium on Nonlinear Dynamics (ISND 2010), September 25-28, Shanghai, China

  • Bulut, B., Çetin, B., Yazıcıoğlu, A., Yuncu, H., Kakaç, S. (2009). "The analysis of the effect of axial conduction on gaseous flow in microchannels by using FEM", 17th National Conference on Thermal Sciences, June 24-27, Sivas, Turkey

  • Çetin, B., Li, D. (2008). "Microfluidic continuous particle separation via AC-DEP with 3D electrodes", ASME International Mechanical Engineering Congress and Exposition (IMECE'08) , October 31-November , Boston, MA, USA

  • Çetin, B., Li, D. (2007). "Modeling and simulation of 2D, EOF in a slit channel with Joule heating effect", 16th National Conference on Thermal Sciences, May 30-June 2, Kayseri, Turkey

  • Bulut, B., Çetin, B., Yazıcıoğlu, A., Yuncu, H., Kakaç, S. (2007). "The analysis of the effect of axial conduction on single-phase convective heat transfer in microtubes", 16th National Conference on Thermal Sciences, May 30-June 2, Kayseri, Turkey

  • Çetin, B., Yuncu, H., Kakaç, S. (2005). "Single-phase convective heat transfer in microtubes", 15th National Conference on Thermal Sciences, September 7-9, Trabzon, Turkey

  • Bayer, O., Çetin, B., Dirgin, E. (2003). "COP-Irreversibility relation in household refrigerators", 14th National Conference on Thermal Sciences, September, 3-5, Isparta, Turkey

    • Journal Papers

  • Cetin, B. (2013). "Effect of thermal creep on heat transfer for a 2D microchannel flow: An analytical approach", Special Issue on Heat Transfer Fluids Engineering & Nanochannels, Microchannels and Minichannels, ASME J. Heat Transfer (In press)

  • Turkmen, I., Baker, D., Cetin, B., Sankır, M. (2013). "Comparison of planar and cylindrical 3–D models for proton exchange membrane fuel cells", In preparation

  • Cetin, B., Celik, B., Sert, C. (2013). "Analysis of heat transfer in slip-flow regime by parallel implementation of Lattice-Boltzmann method on GPUs", Numerical Heat Transfer Part B: Fundamentals (Submitted)

  • Cetin, B., Zeinali, S. (2013). "Analysis of heat transfer for a low Peclet number microtube flow using second-order slip model: An extended-Graetz problem", J. Engineering Mathematics (Submitted)

  • Cole, K., Cetin, B. (2013). "Microchannel heat transfer with slip flow and wall effects", Int. J. Heat and Mass Transfer (Submitted)

  • Buyukkocak, S., Ozer, M., Cetin, B. (2013). "Numerical modeling of acoustophoretic particle separation for microfuildics", In preparation

  • Baranoglu, B., Cetin, B. (2013). "Boundary element formulation of particle flow in a microchannel under the action of hydrodynamic and dielectrophoretic forces", In preparation

  • Çetin, B., Cole, K. (2011). "The effect of axial conduction on heat transfer in a liquid microchannel flow", Int. J. Heat and Mass Transfer, v.54 p. 2542-2549

  • Çetin, B., Bayer, O. (2011). "Evaluation of Nusselt number for a flow in a microtube using second-order slip model", Thermal Science, v.15(Suppl. 1) p.103-109

  • Çetin, B., Li, D. (2011). "Dielectrophoresis in microfluidics technology", Electrophoresis, Special Issue on Dielectrophoresis, v.32 p.2410–2427

  • Çetin, B., Li, D. (2010). "Lab-on-a-chip device for continuous particle and cell separation based on electrical properties via AC-dielectrophoresis ", Electrophoresis, v.31 p.3035-3043

  • Çetin, B., Yazıcıoğlu, A., Kakaç, S. (2009). "Slip-flow heat transfer in microtubes with axial conduction and viscous dissipation-an extended Graetz problem", Int. J. Thermal Sciences, v.48 p.1673-1678

  • Çetin, B., Kang, Y., Wu, Z., Li, D. (2009). "Continuous particle separation by size via AC-DEP using a lab-on-a-chip device with 3D electrodes", Electrophoresis, v.30 p.766-772

  • Çetin, B., Li, D. (2009). "Continuous particle separation based on electrical properties using AC-DEP", Electrophoresis, v.30 p.3124-3133

  • Çetin, B., Kang, Y., Wu, Z., Li, D. (2009). "Continuous particle separation with localized AC-DEP using embedded electrodes and an insulating hurdle", Electrochimica Acta, v.54 p.1715-1720

  • Çetin, B., Yazıcıoğlu, A., Kakaç, S. (2008). "Fluid Flow in microtubes with axial conduction including rarefaction and viscous dissipation", Int. Comm. Heat and Mass Transfer, v.35 p.535-544

  • Çetin, B., Travis, B., Li, D. (2008). "Analysis of the electro-viscous effects on pressure-driven liquid flow in a two-section heterogeneous microchannel", Electrochimica Acta, v.54 p.660-664

  • Çetin, B., Li, D. (2008). "Effect of Joule heating on electrokinetic transport", Electrophoresis, v.29(5) p.994-1005

  • Çetin, B., Yuncu, H., Kakaç, S. (2006). "Gaseous flow in microconduits with viscous dissipation", Int. J. Transport Phenomena, v.8(4) p.297-315

    • M.Sc. Theses

  • Cetin, B. (2005). "Analysis of Single Phase Convective Heat Transfer in Microtubes and Microchannels", METU, Department of Mechanical Engineering, Ankara, Turkey

    • Ph.D. Theses

  • Cetin, B. (2009). "Microfluidic Continuous Separation of Particles and Cells by using AC-Dielectrophoresis", Vanderbilt University, Department of Mechanical Engineering, Nashville, TN, USA



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