Department Seminar by Prof. H. Çağatay Yalçın

Modeling and Visualizing Cardiovascular Blood Flows Can Help to Generate Novel Treatment Strategies to Treat Heart Disease

Prof. H. Çağatay Yalçın, Doğuş University

Date: Friday, May 17, 2013
Time: 10:00
Place: EA 409

Cardiovascular system is a very dynamic system and is composed of heart, blood and the vasculature (veins and arteries). As the pumping mechanism, heart pumps out about 80 mL of blood at about 120mmHg pressure at every heart beat and enables the circulation of about 5 L of blood throughout the body and the lungs constantly. Four heart valves in the heart ensure the unidirectional blood flow through the heart during this circulation. Defects in this dynamic system can disrupt normal blood flow deteriorating O2/CO2 transfers and sometimes even more important than that, can change flow induced forces on heart and vessel walls which may trigger formation of additional defects in the system. Similarly, an artificial organ (like a mechanical heart valve) or a device (like a stent) that are placed into the cardiovascular system in purpose of enhancing system performance, can disrupt the blood flow which may then start biological reactions that can lead to additional defects. Therefore, in order to generate novel treatment techniques for a variety of heart disease, blood flow in the system during disease should be modeled accurately and biological responses of the system components to the forces due to abnormal blood flows should be revealed. This information will be critical in generating intervention and therapeutic approaches that aim to restore blood flow and hence reverse the reactions of the body. This information will also valuable for the development of artificial organs and devices that function compatible with the body.

In that respect, Dr. Yalçın’s research focuses on generating techniques to model or visualize blood flow in the cardiovascular system during a variety of heart disease. Investigating the blood flow in the cardiovascular system during disease, will help to understand the progression of these diseases and come up with tools and strategies to restore the defects.

Dr Yalçın’s studies can be summarized as follows:

· Creating clinically relevant heart defects on test animals (in vivo) for investigation of the biological and genetical development of heart disease.
· Generation of patient spesific cardiovascular computational fluid dynamics models, in order to study clinical progression of heart disease.
· Creating in vitro experimental systems for experimental visualization of the cardiovascular flows during disease.
· Development of mechanical and prosthetic artificial cardiovascular organs and devices.
· Generation of viable substitutes for heart defects using stem cell based tissue engineering approaches.

About the Speaker:

Dr. H. Çağatay Yalçın, received his B.S. from Middle East Technical University in 2001, and PhD from Lehigh University in 2007, in mechanical engineering and bioengineering respectively. He has then worked in the Cardiovascular Developmental Bioengineering Lab at Cornell University as a post-doctoral researcher till 2010. Currently, he is a faculty member of the Doğuş University Mechanical Engineering Department. Dr. Yalçın is married to Olcay Yalçın, who is a mathematics teacher at İSTEK Kemal Atatürk Anatolian High School, and is the father of Ayça Neval and Gökçe Selen.

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