Development of a microfluidic device for synthesis of chitosan nanoparticles

(Ongoing Project)



Project Duration:

Start Date: January 1st, 2013
Expected Completion Date: December 31st, 2015


Chitosan nanoparticles have a biodegradable, biocompatible, non-toxic structure, and are commonly used for drug delivery systems. The objective of the this project is to design, model and fabricate a microfluidic device for the synthesis of chitosan nanoparticles. The microfluidic chip will be fabricated out of PDMS. The fabrication of the mold for the microfluidic device will performed using high-precision micro-machining. Compared to conventional batch-type methods, a microfluidic device can perform the synthesis much faster and in a much automated and convenient manner. The characterization of the synthesis process will also be determined.

Related Publications:

    Journal Papers

  • Çetin, B., Aşık, M.D., Taze, S. (2014). "Design and fabrication of a microfluidic device for synthesis of chitosan nanoparticles", ASME J. Nanotechnology in Engineering and Medicine, v. 4(3) p.031004
    Full Text | DOI: 10.1115/1.4026287

  • Conference Papers

  • Aşık, M.D., Çetin, B., Kaplan, M., Erdem, Y., Sağlam, N. (2016). "3D printed microfluidic reactor for high throughput chitosan nanoparticle synthesis", The 20th Int. Conf. Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), October 9-13, Dublin, Ireland
    Full Text

  • Çetin, B., Taze, S., Aşık, M., Tuncel, A. (2013). "Microfluidic device for synthesis of chitosan nanoparticles", ASME 2013 Fluid Engineering Summer Meeting (16349) p.V002T21A006, July 7-11, Incline village, Nevada, USA
    DOI: 10.1115/FEDSM2013-16349

  • Ph.D. Theses

  • Mehmet Doğan Aşık (Co-supervisor: Asst. Prof. Dr. Barbaros Çetin), (2017). "Design and fabrication of a novel microfluidic device for the synthesis of bio-polimeric nanoparticles", Hacettepe University, Nanotechnology and Nanomedicine, Ankara, Turkey

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