DEVELOPMENT OF A MICROFLUIDIC DEVICE FOR SYNTHESIS OF CHITOSAN NANOPARTICLES

Devam Eden Proje

PROJECT DURATION

Start Date: January 1st, 2013
Expected Completion Date: December 31st, 2015

SUMMARY

Chitosan nanoparticles have a biodegradable, biocompatible, non-toxic structure, and are commonly used for drug delivery systems. The objective of the this project is to design, model and fabricate a microfluidic device for the synthesis of chitosan nanoparticles. The microfluidic chip will be fabricated out of PDMS. The fabrication of the mold for the microfluidic device will performed using high-precision micro-machining. Compared to conventional batch-type methods, a microfluidic device can perform the synthesis much faster and in a much automated and convenient manner. The characterization of the synthesis process will also be determined.

Development of a microfluidic device for synthesis of chitosan nanoparticles

RELATED PUBLICATIONS

  • Özer, M.B., Çetin, B. (2021). "An extended view for acoustofluidic particle manipulation: Scenarios for actuation modes and device resonance phenomenon for bulk-acoustic-wave devices,", J. Acoust. Soc. Am., v.149(4) p.2802–2812, Full Text
  • Aşık, M.D., Kaplan, M., Çetin, B., Sağlam, N. (2021). "Synthesis of iron oxide core chitosan nanoparticles in a 3D printed microfluidic channel", J. Nanopart. Res., v.23(3) p.62, Full Text
  • Sabuncu, A.C., Çetin, B., Usta, O.B., Aubry, N. (2021). "β-dispersion of blood during sedimentation.", Scientific Reports, v.11(1) p.2642, Full Text
  • Atay, A., Topuz, A., Sarıarslan, B., Yıldırım, Y., Charmet, J., Couling, K., Çetin, B. (2021). "Flow rate-controlled pipetting for microfluidics: second-generation flexible hydraulic reservoir (FHRv2)", Microfluid. Nanofluid., v.25(3) p.1-10, Full Text
  • Çetin, B., Kuşcu, Y.F., Çetin, B., Tümüklü, Ö., Cole, K.D. (2021). "Semi-analytical source (SAS) method for 3-D transient heat conduction problems with moving heat source.", Int. J. Heat Mass Trans., v.165 p.120692, Full Text
  • Akkuş, Y., Çetin, B., Dursunkaya, Z. (2020). "A theoretical framework for comprehensive modeling of steadily fed evaporating droplets and the validity of common assumptions", Int. J. Thermal Sciences, v.158 p.106529, Full Text
  • Şahin, M.A., Çetin, B., Özer, M.B. (2020). "Investigation of effect of design and operating parameters on acoustophoretic particle separation via 3D device-level simulations", Microfluid. Nanofluid., v.24(8) p.1-18, Full Text
  • Rasooli, R., Çetin, B. (2019). "An extended Langhaar's solution for two-dimensional entry microchannel flows with high-order slip", Mathematics Applied to Engineering, Modelling, and Social Issues (Editors: Frank Smith, Hemen Dutta and John N. Mordeson), Springer p.189-212, Full Text
  • Çelebi, A.T., Çetin, B., Beşkök, A. (2019). "Molecular and Continuum Perspectives on Intermediate and Flow Reversal Regimes in Electroosmotic Transport", J. Physical Chemistry C, v.123(22) p.14024-14035, Full Text
  • Düven, G., Çetin, B., Kurtuldu, H., Gündüz, G.T., Tavman, Ş., Kışla, D. (2019). "A portable microfluidic platform for rapid determination of microbial load and somatic cell count", Biomed. Microdev., v.21(3) p.49, Full Text
  • Kibar, G., Çalışkan, U., Erdem, Y., Çetin, B. (2019). "One-pot synthesis of polyhedral oligomeric silsesquiox- ane (POSS) microparticles in a microfluidic chip", Full Text
  • Atay, A., Sarıarslan, B., Kuşcu, Y.F., Akkuş, Y., Saygan, S., Gürer, T., Çetin, B., Dursunkaya, Z. (2019). "Experimental dryout characterization of commercial sintered and grooved heat pipes", J. Thermal Science & Technology, v.39(2) p.101-110
  • Akkuş, Y., Çetin, B., Dursunkaya, Z. (2019). "An iterative solution approach to coupled heat and mass transfer in a steadily fed evaporating water droplet", J. Heat Transfer, v.141(2) p.031501, Full Text
  • Alijani, H., Çetin, B., Akkus, Y., Dursunkaya, Z. (2019). "Experimental thermal performance characterization of flat grooved heat pipes", Heat Transfer Engineering, v.40(9-10) p.784–793, Full Text
  • Rasooli, R., Çetin, B. (2018). "Assessment of Lagrangian modeling of particle motion in a spiral microchannel for inertial microfluidics", Micromachines, v.9(9) p.433, Full Text
  • Hatipoğlu, U., Çetin, B., Yıldırım, E. (2018). "A novel zero-dead-volume sample loading interface for microfluidic devices: Flexible Hydraulic Reservoir (FHR)", J. Micromech. Microeng., v.28(9) p.097001, Full Text
  • Oskay, Y., Çetin, B., Şerifoğlu, N., Arslan Ergül, A., Adams, M. (2018). "A novel, low-cost injection and anesthesia system for zebrafish researchers", Zebrafish, v.15(2) p.85-95, Full Text
  • Cole, K., Çetin, B., Demirel, Y. (2018). "Semi-analytical source method for reaction-diffusion problem", J. Heat Transfer, v.140(6) p.061301, Full Text, DOI: http://dx.doi.org/10.1115/1.4038987
  • Düven, G., Çetin, B., Kışla, D. (2018). "Çip-üstü-laboratuvar teknolojisinin gıda mikrobiyolojisindeki uygulamaları (Lab-on-a-chip technology in food microbiology)", Akademik Gıda (Academic Food), v.16(1) p.78-87, Full Text, DOI: http://dx.doi.org/10.24323/akademik-gida.417895
  • Alijani, H., Çetin, B., Akkus, Y., Dursunkaya, Z. (2018). "Effect of design and operating parameters on the thermal Performance of flat grooved heat pipes", Applied Thermal Engineering, v.132 p.174-187, Full Text
  • Yıldıran, İ.N., Temizer, İ., Çetin, B. (2017). "Homogenization in Hydrodynamic Lubrication: Microscopic Regimes and Re-Entrant Textures", Journal of Tribology, v.140 p.011701 (1-19), Full Text, DOI: http://tribology.asmedigitalcollection.asme.org/article.aspx?articleid=2628741
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  • Akkuş, Y., Tarman, H.İ., Çetin, B., Dursunkaya, Z. (2017). "Two-dimensional computational modeling of thin film evaporation", Int. J. Thermal Sciences, v.121 p.237–248, Full Text
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  • Çetin, B., Öner, S.D., Baranoğlu, B. (2017). "Modeling of dielectrophoretic particle motion: Point particle vs finite-sized particle", Electrophoresis, v.38 p.1407-1418, Full Text, DOI: http://dx.doi.org/10.1002/elps.201600461
  • Kerse, C., Kalaycıoğlu, H., Elahi, P., Yavaş, S., Kesim, D., Akçaalan, Ö., Öktem, B., Çetin, B., Aşık, M., Hoogland, H., Holzwarth, R., İlday, F.Ö. (2016). "Ablation-cooled material removal with ultrafast bursts of pulses", Nature, v.537 p.84-88, Full Text, DOI: http://dx.doi.org/doi:10.1038/nature18619
  • Çetin, B., Özer, M.B., Çağatay, E., Büyükkoçak, S. (2016). "An integrated acoustic and dielectrophoretic particle manipulation in a microfluidic device for particle wash and separation fabricated by mechanical machining", Biomicrofluidics, v.10 p.014112, Full Text, DOI: http://dx.doi.org/http://dx.doi.org/10.1063/1.4940431
  • Yavuz, C., Oliaei, S.N., Çetin, B., Yeşil-Çeliktaş, Ö. (2016). "Sterilization of PMMA microfluidic chips by various techniques and investigation of material characteristics", J. Supercrticial Fluids, v.107 p.114–121, Full Text, DOI: http://dx.doi.org/10.1016/j.supflu.2015.08.019
  • Çetin, B., Yıldırım, E., Akay, Ş. (2016). "Mikroakışkan Sistemlerin Üretimi", Mikroakışkan Teknolojilerin Temelleri ve Uygulamaları (Edited by Assoc. Prof. Ö. Yeşil-Çeliktaş) p.27–51
  • Yavuz, C., Çetin, B., Yeşil-Çeliktaş, Ö. (2016). "Mikroakışkan Sistemlerin Sterilizasyonu", Mikroakışkan Teknolojilerin Temelleri ve Uygulamaları (Edited by Assoc. Prof. Ö. Yeşil-Çeliktaş) p.115–137
  • Yeşil-Çeliktaş, Ö., Çetin, B., Yıldırım, E. (2016). "Mikroakışkan Sistemlere Yönelik Gelecek Tahminleri", Mikroakışkan Teknolojilerin Temelleri ve Uygulamaları (Edited by Assoc. Prof. Ö. Yeşil-Çeliktaş) p.199–204
  • Zeinali, S., Çetin, B., Oliaei, S., Karpat, Y. (2015). "Fabrication of continuous flow microfluidics device with 3D electrode structures for high throughput DEP applications using mechanical machining", Electrophoresis, Special Issue on Dielectrophoresis, v.36(13) p.1432-1442, Full Text, DOI: http://dx.doi.org/10.1002/elps.201400486
  • Barışık, M., Yazıcıoğlu, A.G., Çetin, B., Kakaç, S. (2015). "Analytical solution of thermally developing microtube heat transfer including axial conduction", Int. Comm. Heat and Mass Transfer, v.67 p.81-88, Full Text
  • Karakaya, Z., Baranoğlu, B., Çetin, B., Yazıcı, A. (2015). "A parallel boundary element formulation for tracking multiple particle trajectories in Stoke's flow for microfluidic applications", CMES-Computer Modeling in Engineering and Science, v.104(3) p.227-249, Full Text
  • Çetin, B., Koska, K., Erdal, M. (2015). "Warpage Characterization of Microchannels Fabricated by Injection Molding", ASME J. Micro and Nano-Manufacturing, v.3(2) p.021005, Full Text
  • Çetin, B., Li, D. (2015). "Temperature Gradient Generation and Control", Encyclopedia of Micro and Nanofluidics (2nd Edition), Springer p.3225-3227
  • Çetin, B., Baranoğlu, B. (2015). "Boundary-Element Method in Microfluidics", Encyclopedia of Micro and Nanofluidics (2nd Edition), Springer p.202-213
  • Çetin, B., Salemmilani, R., Li, D. (2015). "Microfluidic Rotary Pump", Encyclopedia of Micro and Nanofluidics (2nd Edition), Springer p.2000-2004
  • Çetin, B., Salemmilani, R., D. Li (2015). "Ultrasonic pumps", Encyclopedia of Micro and Nanofluidics (2nd Edition), Springer p.3394-3397
  • Çetin, B., Zeinali, S., Li, D. (2015). "Microfluidic Optical Devices", Encyclopedia of Micro and Nanofluidics (2nd Edition), Springer p.1980-1984
  • Çetin, B., Zeinali, S., Li, D. (2015). "Magnetic Pumps", Encyclopedia of Micro and Nanofluidics (2nd Edition) p.1690-1695
  • Çetin, B., Taze, S., Li, D. (2015). "Methods for Pressure Measurements", Encyclopedia of Micro and Nanofluidics (2nd Edition), Springer p.2828-2834
  • Büyükkoçak, S., Özer, M.B., Çetin, B. (2015). "Microscale Acoustofluidics", Encyclopedia of Micro and Nanofluidics (2nd Edition), Springer p.2149-2158
  • Büyükkoçak, S., Özer, B., Çetin, B. (2014). "Numerical modeling of acoustophoretic particle separation for microfuildics", Microfluid Nanofluid, v.17(6) p.1025-1037, Full Text
  • Çetin, B., Zeinali, S. (2014). "Analysis of heat transfer for a low Peclet number microtube flow using second-order slip model: An extended-Graetz problem", J. Engineering Mathematics, v.89(1) p.13-25, Full Text
  • Çetin, B., Özer, M.B., Solmaz, M.E. (2014). "Microfluidic bio-particle manipulation for biotechnology", Biochemical Engineering Journal, v.92 p.63-82, Full Text
  • Cole, K., Çetin, B., Brettmann, L. (2014). "Microchannel heat transfer with slip flow and wall effects", AIAA J. Thermophysics and Heat Transfer, v.28(3) p.455-462, Full Text
  • Çetin, B., Aşık, M.D., Taze, S. (2014). "Design and fabrication of a microfluidic device for synthesis of chitosan nanoparticles", ASME J. Nanotechnology in Engineering and Medicine, v.4(3) p.031004, Full Text
  • Çetin, B. (2013). "Effect of thermal creep on heat transfer for a 2D microchannel flow: An analytical approach", ASME J. Heat Transfer, Special Issue on Microchannel Heat Transfer, v.135(10) p.101007, Full Text
  • Çetin, B., Li, D. (2011). "Dielectrophoresis in microfluidics technology", Electrophoresis, Special Issue on Dielectrophoresis, v.32 p.2410–2427
  • Çetin, B., Bayer, O. (2011). "Evaluation of Nusselt number for a flow in a microtube using second-order slip model", Thermal Science, v.15(Suppl. 1) p.103-109, Full Text
  • Çetin, B., Cole, K. (2011). "The effect of axial conduction on heat transfer in a liquid microchannel flow", Int. J. Heat and Mass Transfer, v.54 p.2542-2549, DOI: http://dx.doi.org/10.1016/j.ijheatmasstransfer.2011.02.007
  • Çetin, B., Li, D. (2010). "Lab-on-a-chip device for continuous particle and cell separation based on electrical properties via AC-dielectrophoresis", Electrophoresis, v.31 p.3035-3043, DOI: http://dx.doi.org/10.1002/elps.20090007830
  • Çetin, B., Yazıcıoğlu, A.G., Kakaç, S. (2009). "Slip-flow heat transfer in microtubes with axial conduction and viscous dissipation-an extended Graetz problem", Int. J. Thermal Sciences, v.48 p.1673-1678, DOI: http://dx.doi.org/10.1016/j.ijthermalsci.2009.02.002
  • Çetin, B., Kang, Y., Wu, Z., Li, D. (2009). "Continuous particle separation with localized AC-DEP using embedded electrodes and an insulating hurdle", Electrochimica Acta, v.54 p.1715-1720, DOI: http://dx.doi.org/10.1016/j.electacta.2008.09.062
  • Çetin, B., Kang, Y., Wu, Z., Li, D. (2009). "Continuous particle separation by size via AC-DEP using a lab-on-a-chip device with 3D electrodes", Electrophoresis, v.30 p.766-772, DOI: http://dx.doi.org/10.1002/elps.200800464
  • Çetin, B., Li, D. (2009). "Continuous particle separation based on electrical properties using AC-DEP", Electrophoresis, v.30 p.3124-3133, DOI: http://dx.doi.org/10.1002/elps.20090007830
  • Çetin, B., Yazıcıoğlu, A.G., Kakaç, S. (2008). "Fluid Flow in microtubes with axial conduction including rarefaction and viscous dissipation", Int. Comm. Heat and Mass Transfer, v.35 p.535-544, DOI: http://dx.doi.org/10.1016/j.icheatmasstransfer.2008.01.003
  • Çetin, B., Li, D. (2008). "Effect of Joule heating on electrokinetic transport", Electrophoresis, v.29(5) p.994-1005, DOI: http://dx.doi.org/10.1002/elps.200700601
  • Çetin, B., Travis, B.E., Li, D. (2008). "Analysis of the electro-viscous effects on pressure-driven liquid flow in a two-section heterogeneous microchannel", Electrochimica Acta, v.54 p.660-664, DOI: http://dx.doi.org/10.1016/j.electacta.2008.07.008
  • Çetin, B., Yuncu, H., Kakaç, S. (2006). "Gaseous flow in microconduits with viscous dissipation", Int. J. Transport Phenomena, v.8(4) p.297-315, Full Text
  • Çetin, B., Li, D. (2008). "Microfluidic Rotary Pump", Encyclopedia of Micro and Nanofluidics (1st Edition), Springer p.1188-1189, Full Text
  • Çetin, B., Li, D. (2008). "Temperature Gradient Generation and Control", Encyclopedia of Micro and Nanofluidics (1st Edition), Springer p.1993-1994, Full Text
  • Çetin, B., Li, D. (2008). "Methods for Pressure Measurements", Encyclopedia of Micro and Nanofluidics (1st Edition), Springer p.1743-1745, Full Text
  • Çetin, B., Li, D. (2008). "Magnetic Pumps", Encyclopedia of Micro and Nanofluidics (1st Edition), Springer p.1040-1043, Full Text
  • Çetin, B., Li, D. (2008). "Microfluidic Optical Devices", Encyclopedia of Micro and Nanofluidics (1st Edition), Springer p.1186-1187, Full Text
  • Çetin, B., Li, D. (2008). "Ultrasonic pumps", Encyclopedia of Micro and Nanofluidics (1st Edition), Springer p.2128-2129, Full Text