Microfluidics requires dynamic spatial and temporal fluid control to unlock applications like 3D bioprinting and advanced assays. This presentation addresses this need by introducing novel strategies for precise fluid manipulation. First, we analyze and achieve precise flow stoppage (residual velocity) by identifying and engineering solutions for fluidic circuit compliance (tubing and wall elasticity). Building on this foundational control, we introduce ActiSculpt, a modular platform for real-time, spatiotemporal sculpting of laminar co-flows. By integrating hydrodynamic stacking with surface acoustic wave (SAW) actuation, we dynamically deform fluid interfaces on demand, transforming fluid morphology into a tunable design parameter for programmable material fabrication. Finally, we translate this precision into a new compartmentalization technology: Lab-on-a-Particle (LoaP) and Lab-on-a-Fiber (LoaF). We detail the batch-manufacturing of shape-coded, multi-material particles that create uniform micro-compartments (‘dropicles’) for scalable, multiplexed single-entity assays, demonstrating a highly sensitive diagnostic platform.